San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team officially dubbed a knee injury. The 28-year-old gave himself before being touched, and immediately ran to the sideline before being taken to the locker room.

Facing their seventh loss of the season, 49ers HC Kyle Shanahan gave an update on RB Christian McCaffrey who left the game with a knee injury.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A knee injury also knocked the running back out of Sunday night's Week 13 matchup with the Buffalo Bills,

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second quarter against the Buffalo Bills.