San Francisco 49ers star Christian McCaffrey is believed to have suffered a PCL injury during the Niners’ 35-10 loss to the Buffalo Bills Sunday, head coach Kyle Shanahan said after the game. It could be season-ending, USA TODAY reported.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A knee injury knocked the running back out of Sunday night's Week 13 matchup with the Buffalo Bills,

San Francisco enters Week 14 with a 5-7 record. The 49ers return to the Bay for a two-game homestand that includes a quick turnaround. They'll face the Bears on Sunday before returning to the field for "Thursday Night Football" in Week 15.

Christian McCaffrey may be done for the rest of 2024. Following Sunday’s 35-10 loss to the Bills, 49ers head coach Kyle Shanahan told reporters in his postgame press conference that McCaffrey suffered a PCL injury that could be season-ending.

The worst fears for the San Francisco 49ers and star Christian McCaffrey may have been realized, as the star running back did not return to Sunday’s snowy game in Buffalo after exiting with a non-contact injury.

The 49ers running back went down with a non-contact knee injury early in San Francisco's 35-10 loss to the Buffalo Bills on Sunday night. Head coach Kyle Shanahan said after the game at Highmark Stadium that McCaffrey sustained a "potentially" season-ending PCL injury. Further specifics are not yet known.

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey suffered a PCL injury in his right knee in what is feared to be season-ending, according to 49ers head coach Kyle Shanahan.

San Francisco 49ers running back Christian McCaffrey's season might be over after he suffered a PCL injury on "Sunday Night Football."

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle Shanahan said Sunday night.