DEPTAC. Based on PROTACs, or protein-targeting chimeras, D20, a dephosphorylation-targeting chimera, delivers PP1 to tau. The C-terminal tail (gray) helps the construct enter cells. [Courtesy of Xiao ...
Two of the groups reported that cultured human oligodendrocytes make as much or more Aβ than do neurons, and that ...
Two of the groups reported that cultured human oligodendrocytes make as much or more Aβ than do neurons, and that ...
A new single-cell omics model might help scientists better understand brain function. As reported in the September 24 Nature Neuroscience, researchers led by Kate Meyer, Duke University, Durham, North ...
About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic ...
Driving the Amyloid Cascade? A microglial subtype, Mic.12, promotes plaque deposition, while another, Mic.13, promotes ...
Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are ...
L444P KI mice were generated using a loxP replacement vector, resulting in the insertion of a point mutation of leucine to proline (L444P) in exon 10 of the Gba1 gene (Ginns et al., 2014). These Gba1 ...
The findings indicate that early changes in brain activity—happening in parallel with Aβ and tau accumulation—can predict future cognitive decline. “This suggests that we may be able to detect ...
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