The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

Former Wisconsin running back Isaac Guerendo scored the second touchdown of his young NFL career in the San Francisco 49ers’ ...

The San Francisco 49ers entered Sunday night's matchup against the Buffalo Bills at Highmark Stadium without several key ...

San Francisco 49ers’ Christian McCaffrey is one of the most exciting talents in NFL. While his professional accomplishments ...

San Francisco 49ers’ Christian McCaffrey is one of the most exciting talents in NFL. While his professional accomplishments ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

The tragedy of this 49ers’ season epitomized. For the first time since returning to the lineup in Week 10, McCaffrey looked ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.