Injuries continue to mount around the NFL, and with Thanksgiving in the rearview mirror — and playoff berths already clinched — the push is on to get healthy for the stretch run. But a couple of teams that were thought to be among the playoff contenders at the start of the year have had their seasons derailed by trips to the trainer's table.

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team officially dubbed a knee injury. The 28-year-old gave himself before being touched, and immediately ran to the sideline before being taken to the locker room.

Christian McCaffrey ’s challenging 2024 NFL season took a devastating turn on Sunday when the San Francisco 49ers ’ star running back sustained a potential season-ending injury in a 35-10 loss to the Buffalo Bills.