The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on the season. With their playoff hopes dwindling, questions are mounting ...

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back ...

San Francisco 49ers star running back Christian McCaffrey's season is in jeopardy after he sustained what is believed to be a ...

San Francisco 49ers tight end George Kittle told reporters he had "no idea" why he received just two targets during a 35-10 ...

As the 49ers anxiously await the results of McCaffrey’s MRI scans on Monday, the star running back’s dad, Ed, shared his honest thoughts on his son’s latest injury on the Up & Adams Show.

The Los Angeles Rams' bitter rival suffered yet another devastating injury during their Week 13 road loss against the Buffalo ...

San Francisco 49ers star Christian McCaffrey is believed to have suffered a PCL injury during the Niners’ 35-10 loss to the ...

But now it is back to the drawing board, not only for McCaffrey, but the 49ers at large. His injury, of course, is just one ...

Head coach Kyle Shananhan said running back Christian McCaffrey suffered a knee injury during the team's 35-10 loss to the ...

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle ...

Christian McCaffrey faces a potential season-ending PCL injury, confirmed non-surgical but sidelining him for multiple weeks ...