Jared Goff threw two touchdown passes to Sam LaPorta, Jake Bates made three field goals in the first half and the Detroit ...

This week, Nick Bosa was asked about the 49ers' upcoming opponent, Bills quarterback Josh Allen. Here's what Bosa said. Q: ...

The Buffalo Bills look set to face the San Francisco 49ers in wild conditions with heavy snow continuing to fall in the area ...

The Bears were left with a last-ditch effort to convert and they did when officials flagged Bears defensive back Kindle ...

While honoring the late John Madden with jersey patches on their uniforms, the Lions' defense also pitched a first-half ...

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio ...

Detroit Lions (10-1) host Chicago Bears (4-7) on Thanksgiving hoping to snap a 7-game losing streak on the holiday. Follow ...

The Bills attempt to win seven in a row when they host the 49ers in this Week 13 NFL odds, prediction, and pick.

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on “Sunday Night Football” in Week 13. The ...

WR Curtis Samuel (vs. 49ers) — Samuel made mincemeat out of the Chiefs in his last game. But with Keon Coleman and Dalton ...

How much weight do you want to put on the frozen-Fish angle? The forecast at Lambeau is 21 degrees, a real feel of 4 with 15 ...

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...