In Sporting News' latest weekly game picks and predictions against the spread for Week 13, the Bills keep the 49ers reeling, ...

San Francisco quarterback Brock Purdy, after missing one game because of an ailing right shoulder, will start for the 49ers ...

Although there aren't any teams on bye in Week 13, we already have four games in the books heading into Sunday thanks to the ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

Leonard Williams almost certainly will win NFC Defensive Player of the Week honors for his efforts in Sunday's 26-21 victory over the New York Jets. Williams had a 92-yard INT return for a TD, two ...

After their 38-10 loss to the Packers at Lambeau Field in Green Bay on Sunday, the San Francisco 49ers felt like a team whose ...

Purdy is officially listed as questionable for the game, though coach Kyle Shanahan said the plan is for him to start on ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in ...

Thanksgiving leaves many lethargic and in a food coma, but 22 NFL teams will have to shake off that rust as a full slate of ...

There are no teams on bye around the NFL in Week 13, which means we'll be treated to a packed slate of Sunday games even ...

It's been a season full of special teams disasters for the 49ers, with the missed field goals, poor return coverage and ...