The 49ers are down to one healthy RB, rookie Isaac Guerendo. They will likely elevate Patrick Taylor Jr. from the practice ...

The San Francisco 49ers' dreadful season got worse in Week 13 when running backs Christian McCaffrey and Jordan Mason both ...

Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

McCaffrey suffered a PCL injury during Sunday's loss to the Bills, while Mason goes on IR with a high ankle sprain.

San Francisco 49ers star Christian McCaffrey left Sunday night’s 35-10 loss to the Buffalo Bills with a knee injury, but it ...

With Christian McCaffrey's health once again in question, Jordan Mason gets second chance to lead 49ers backfield.

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

The San Francisco 49ers plan to place running backs Christian McCaffrey and Jordan Mason on injured reserve after suffering ...

As the San Francisco 49ers confirmed Christian McCaffrey suffered a likely season-ending injury, his backup, Jordan Mason, ...

The San Francisco 49ers entered this season with lofty aspirations. For the most part, their hopes have been dashed -- and ...

An extremely disappointing season for Christian McCaffrey, which encapsulates the distressing tone of the San Francisco 49ers ...