San Francisco 49ers running back Christian McCaffrey left Sunday's game and didn't return. Now his season is in question.

San Francisco 49ers head coach Kyle Shanahan revealed after Sunday night's loss to the Buffalo Bills that running back ...

One last note of the bizarre: Niners tight end and eternal optimist George Kittle referenced a speech Shanahan gave back in ...

San Francisco has dropped three straight, including meek losses to the Packers and Bills by a combined 53 points, to drop to ...

The San Francisco 49ers endured another disheartening loss Sunday night, falling to the Buffalo Bills and dropping to 5-7 on ...

As the 49ers anxiously await the results of McCaffrey’s MRI scans on Monday, the star running back’s dad, Ed, shared his honest thoughts on his son’s latest injury on the Up & Adams Show.

But now it is back to the drawing board, not only for McCaffrey, but the 49ers at large. His injury, of course, is just one ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

Matthew Berry, Jay Croucher and Connor Rogers dive into the ramifications of star Christian McCaffrey's latest injury, ...

The Los Angeles Rams' arch-rival just received even more terrible injury news regarding running back Christian McCaffrey The ...

The New York Jets plan to keep Aaron Rodgers as the starting quarterback, despite his struggles and 3-9 record this season, ...

Replacing McCaffrey won't be easy for fantasy football managers, but these three running backs present the most viable ...