Catch up on the latest San Francisco 49ers headlines, powered by..... 49ers Notebook: Reflecting on playing in snowy weather; ...

In a heart-stopping moment that left San Francisco 49ers fans holding their breath, Christian McCaffrey's injury scare during ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

San Francisco 49ers star Christian McCaffrey could "potentially" be lost for the season with a knee injury, head coach Kyle ...

Well, that wasn't fun. The San Francisco 49ers looked like they were cooking early in the game, but eventually, the Buffalo ...

Los San Francisco 49ers visitaron el Highmark Stadium para enfrentar a los Buffalo Bills. San Francisco sufrió una derrota 35 ...

Injuries and missed opportunities have defined the San Francisco 49ers' 2024 season. Can they overcome setbacks and make a ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

The San Francisco 49ers clearly struggled to adapt to the weather in Buffalo on Sunday night, and it showed, as the Bills ...

Christian McCaffrey ’s challenging 2024 NFL season took a devastating turn on Sunday when the San Francisco 49ers ’ star ...

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ...

San Francisco 49ers quarterback Brock Purdy feels sorry for the brutal injury suffered by Christian McCaffrey.